Autoantibodies Targeting Nephrin in Podocytopathies
Authors' conclusion
In this study, circulating antinephrin autoantibodies were common in patients with minimal change disease or idiopathic nephrotic syndrome and appeared to be markers of disease activity.
Study context
- Population
- Adults with glomerular diseases and children with idiopathic nephrotic syndrome, plus controls357 adults · 182 children
- Participants
- 539 participants
- Exposure
- Minimal change disease vs Primary focal segmental glomerulosclerosis vs Idiopathic nephrotic syndrome vs Other conditions vs Controls
- Minimal change diseasen = 105
- Primary focal segmental glomerulosclerosisn = 74
- Idiopathic nephrotic syndromen = 182
- Controlsn = 117reference
- Outcome
- Prevalence of antinephrin autoantibodies
Methodological detailsmulticentre, experimental mouse model (active immunization with recombinant murine nephrin)
- Multicentre
- Experimental mouse model (active immunization with recombinant murine nephrin)
Main finding
As reported in the abstract
Antinephrin autoantibodies
Observational data: associations, not effects.
Further findings
Antinephrin autoantibodies in active MCD or idiopathic nephrotic syndrome without immunosuppressive treatment (subgroup)
Antinephrin autoantibody levels and disease activity · at inclusion and during follow-up
- Levels correlated with disease activity
Experimental immunization in mice
- Induced nephrotic syndrome, MCD-like phenotype, IgG localization to podocyte slit diaphragm, nephrin phosphorylation and severe cytoskeletal changes
Original publication
Autoantibodies Targeting Nephrin in Podocytopathies. N Engl J Med. Published 25 May 2024. doi:10.
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