Polyarticular juvenile idiopathic arthritis has a distinct co-inhibitor receptor profile
Authors' conclusion
Polyarticular JIA patients had a different co-IR profile, having more CTLA-4, PD-1 and 4-1BB in their plasma than the other subtypes of JIA.
Study context
- Population
- JIA patients sampled at onset or during flare, and healthy controls
- Participants
- 67 / 12 / 17 / 11 / 10
- Comparison
- Polyarticular JIA vs other JIA subtypes and healthy controls
- Oligoarticular JIAn = 67
- Polyarticular JIAn = 12
- Enthesitis-related arthritisn = 17
- Systemic JIAn = 11
- Healthy controlsn = 10reference
- Outcome
- Plasma soluble co-IR levels
Main finding
As reported in the abstract
- Polyarticular JIA vs Other JIA subgroups and healthy controls: P < 0.001
- Polyarticular JIA vs Other JIA subgroups and healthy controls: P < 0.05
- Polyarticular JIA vs Other JIA subgroups and healthy controls: P < 0.05
Further findings
| Outcome | P value |
|---|---|
| CTLA4 surface expression on PBMCsPolyarticular JIA vs Other JIA subgroups | P < 0.05 |
| CTLA4 surface expression on PBMCsPolyarticular JIA vs Other JIA subgroups | P < 0.01 |
Original publication
Polyarticular juvenile idiopathic arthritis has a distinct co-inhibitor receptor profile. Rheumatology (Oxford). Published 23 May 2024. doi:10.
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