Single center clinical analysis of macrophage activation syndrome complicating juvenile rheumatic diseases
Authors' conclusion
Thrombocytopenia, ferritin levels, the ferritin/erythrocyte sedimentation rate, and elevated aspartate aminotransferase levels can predict the occurrence of MAS in patients with sJIA.
Study context
- Population
- Children with rheumatic diseases complicated by macrophage activation syndrome (MAS), single centre, January 2017–December 2022
- Participants
- 55 children
- Exposure
- sJIA-MAS vs active systemic juvenile idiopathic arthritis (sJIA); MAS across sJIA, Kawasaki disease (KD) and systemic lupus erythematosus (SLE)
- Outcome
- MAS during initial diagnosis of the underlying disease
Methodological detailssingle-centre, random forest model
- Single-centre
- Random forest model
Main finding
As reported in the abstract
MAS occurring during initial diagnosis of the underlying disease
81.8%
Observational data: associations, not effects.
Further findings
- No deaths occurred
- Most treated with methylprednisolone pulse plus cyclosporine
Original publication
Single center clinical analysis of macrophage activation syndrome complicating juvenile rheumatic diseases. Pediatr Rheumatol Online J. Published 23 May 2024. doi:10.
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