Vasculitis & polymyalgia rheumatica
Associations between plasma metabolism-associated proteins and future development of giant cell arteritis: results from a prospective study
Main finding · Association of a priori hypothesised metabolism-associated plasma proteins with subsequent GCAResult — go to the resultOdds ratio per S.D. (FBP1) 0.59 95% CI 0.35–0.99Authors' conclusion
Biomarkers identified years before clinical diagnosis indicated a protective role of gluconeogenesis (FBP1) and an association with macrophage activation (ADGRE2 and Metrnl) and proinflammatory signals (ROR1) for development of GCA.
Study context
- Population
- Participants of the population-based Malmö Diet Cancer Study (MDCS; N = 30,447); baseline plasma samplesMDCS N = 30,447
- Comparison
- Incident GCA cases vs matched GCA-free controls
- GCAn = 95
- Outcome
- Association of baseline metabolism-associated plasma proteins with subsequent GCA
Methodological detailsprospective population-based cohort, matched controls, hypothesis-driven and hypothesis-generating analyses, OLINK proteomics metabolism panel (92 proteins), GCA diagnosed median 12.0 years after inclusion
- Prospective population-based cohort
- Matched controls
- Hypothesis-driven and hypothesis-generating analyses
- OLINK proteomics metabolism panel (92 proteins)
- GCA diagnosed median 12.0 years after inclusion
Main finding
As reported in the abstract
Association of a priori hypothesised metabolism-associated plasma proteins with subsequent GCA
Odds ratio per S.D. (FBP1)
0.59
95% CI 0.35–0.99
GCAvs Controls
OR per S.D. (FBP1) 0.59 (95% CI 0.35–0.99)
Observational data: associations, not effects.
Further findings
ADGRE2, subset sampled <8.5 years before diagnosis
- ADGRE2 levels associated with subsequent GCA
Metrnl by time to GCA
- Highest impact on GCA risk in those sampled closest to diagnosis, decreasing trend with longer time to GCA
- P = 0.03
ROR1 (hypothesis-generating analyses)
- Elevated ROR1 levels associated with subsequent GCA
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Associations between plasma metabolism-associated proteins and future development of giant cell arteritis: results from a prospective study. Rheumatology (Oxford). Published 3 February 2024. doi:10.
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