Vasculitis & polymyalgia rheumatica
Apolipoproteins and the risk of giant cell arteritis—a nested case–control study
Main finding · ApoA-I at baseline screeningResult — go to the resultOdds ratio per SD 1.57 95% CI 1.18–2.10Authors' conclusion
Subsequent development of GCA was associated with significantly higher levels of ApoA-I.
Study context
- Population
- Participants of a population-based health survey (Malmö Diet Cancer Study; N = 30,447) who developed giant cell arteritis (GCA), and matched controls100 GCA cases
- Exposure
- GCA cases vs matched controls
- Casesn = 100
- Outcome
- Relation between baseline apolipoprotein levels (apolipoprotein A-I (ApoA-I), ApoB) and future diagnosis of GCA
Methodological detailspopulation-based, 4 controls per case, matched for sex, year of birth and year of screening, conditional logistic regression
- Population-based
- 4 controls per case, matched for sex, year of birth and year of screening
- Conditional logistic regression
Main finding
ApoA-I at baseline screening
Odds ratio per SD
1.57
95% CI 1.18–2.10
By group
Casesvs Controls
OR per SD 1.57 (95% CI 1.18–2.10)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mean, mg/dL
| Outcome | Cases | Controls | OR per SD (95% CI) | |
|---|---|---|---|---|
| ApoB at baseline screeningSD 27.1 mg/dL | 109.3 | 110.4 | 0.99 (0.74–1.32) | |
| ApoA-I, adjusted for BMI and physical activity | 1.48 (1.09–1.99) | |||
| 0.512Odds ratio per SD (log scale) |
Apolipoprotein B (ApoB)/ApoA1 ratio
- Tended to be lower in cases than in controls, but the difference did not reach significance
Original publication
Apolipoproteins and the risk of giant cell arteritis—a nested case–control study. Arthritis Res Ther. Published 27 January 2024. doi:10.
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