Vasculitis & polymyalgia rheumatica
Development of the Takayasu Arteritis Integrated Disease Activity Index
Authors' conclusion
TAIDAI is new type of disease activity index in TAK in which clinical symptoms are integrated with specific laboratory and imaging findings.
Study context
- Population
- Patients with TAK in a prospective observational cohort
- Participants
- 96 patients204 study visits
- Exposure
- Takayasu's Arteritis Integrated Disease Activity Index (TAIDAI) vs physician's clinical assessment
- Outcome
- Performance of TAIDAI vs physician's clinical assessment
Methodological detailsindex development, validation study
- Index development
- Validation study
Main finding
As reported in the abstract
| Group | Sensitivity | Specificity |
|---|---|---|
| TAIDAI | 96.3% | 79.2% |
TAIDAI
Sensitivity96.3%
Specificity79.2%
- Seventeen clinical symptoms paired with imaging or laboratory abnormalities
- 17
Observational data: associations, not effects.
Further findings
- Sensitivity to change: TAIDAI of 0 in clinical responders treated with TNFi or tocilizumab
- 91% · 21 events
- Sensitivity to change: TAIDAI of 0 in clinical responders treated with TNFi or tocilizumab: of 23 patients who met a predefined definition of clinical response
Correlations of TAIDAI
- TAIDAI significantly correlated with PGA, PET Vascular Activity Score, patient global assessment and acute phase reactant levels
Original publication
Development of the Takayasu Arteritis Integrated Disease Activity Index. Arthritis Care Res (Hoboken). Published 26 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →