Vasculitis & polymyalgia rheumatica

Adherence to dietary recommendations and the risk of developing giant cell arteritis: A nested Case-Control study

Semin Arthritis RheumPublished Nested case-control study

Main finding · Development of GCAResult — go to the resultAdjusted odds ratio 2.70 95% CI 1.43–5.10

Authors' conclusion

An overall high diet quality was independently associated with an increased risk of GCA.

Study context

Population
Participants in the Malmö Diet and Cancer Study cohort who subsequently developed giant cell arteritis (GCA), with matched controls193 incident GCA cases
Comparison
High vs low adherence to dietary guidelines
Outcome
Development of GCA
Methodological details4 controls per case, matched for age, sex and year of inclusion, logistic regression adjusted for total energy intake, leisure-time physical activity and alcohol intake, potential misreporters of total energy intake excluded
  • 4 controls per case, matched for age, sex and year of inclusion
  • Logistic regression adjusted for total energy intake, leisure-time physical activity and alcohol intake
  • Potential misreporters of total energy intake excluded

Main finding

As reported in the abstract

Adjusted odds ratio

2.70

95% CI 1.43–5.10

SDGS 4-5vs SDGS 0-1
aOR 2.70 (95% CI 1.43–5.10)

Observational data: associations, not effects.

Further findings

Adherence to individual recommendations and GCA risk (adjusted)

Adherence to recommended intake of added sugar, fish and shellfish, and vegetables and fruit associated with increased GCA risk

Quantified intake of components and GCA risk

Reduced risk with higher added sugar consumption
Increased risk with higher intakes of fiber and fish and shellfish

Original publication

Adherence to dietary recommendations and the risk of developing giant cell arteritis: A nested Case-Control study. Semin Arthritis Rheum. Published 29 May 2026. doi:10.1016/j.semarthrit.2026.153003

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