Vasculitis & polymyalgia rheumatica
Progression to antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in patients with idiopathic interstitial pneumonia and positive ANCA
Authors' conclusion
Approximately 10 % of ANCA-positive IIP patients developed AAV after an IIP diagnosis. Anti-MPO or co-occurring positive RF poses a significant risk for subsequent AAV occurrence.
Study context
- Population
- Patients with idiopathic interstitial pneumonia (IIP) and positive ANCA without AAV, single tertiary centre, South Korea, January 2013 to August 2023
- Participants
- 154 patients
- Exposure
- Patients who developed AAV vs those who did not
- Outcome
- Development of AAV after IIP diagnosis and its risk factors
Methodological detailssingle-centre, tertiary centre, Cox regression, Kaplan-Meier analysis
- Single-centre
- Tertiary centre
- Cox regression
- Kaplan-Meier analysis
Main finding
As reported in the abstract
Development of AAV
Proportion of ANCA-positive IIP patients who eventually developed AAV
10.4 %
Observational data: associations, not effects.
Further findings
RF positivity
P = 0.007
| Outcome | AAV | Non-AAV | P value |
|---|---|---|---|
| Anti-MPO positivity | All | 48.8 % | P < 0.001 |
Baseline characteristics (sex, age, smoking status, urinalysis, chest CT findings)
- No significant difference between AAV and non-AAV groups
Risk factors for AAV occurrence (multivariate Cox regression and Kaplan-Meier)
- Rheumatoid factor (RF) positivity, HR (P = 0.004)
- 4.02
- Anti-MPO positivity, HR (P < 0.001)
- 38.10
Original publication
Progression to ANCA-associated vasculitis in patients with idiopathic interstitial pneumonia and positive ANCA. Semin Arthritis Rheum. Published 30 May 2024. doi:10.
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