Vasculitis & polymyalgia rheumatica
Association of Somatic TET2 Mutations With Giant Cell Arteritis
Main finding · Incident GCAResult — go to the resultFold increased risk 1.48Authors' conclusion
CH increases risk for development of GCA in a genotype-specific manner, with the greatest risk being conferred by the presence of mutations in TET2. Somatic TET2 mutations likewise increase the risk of GCA-associated vision loss.
Study context
- Population
- UK Biobank participants with sequenced exomes; institutional cohort of patients with giant cell arteritis (GCA)plus 114 institutional GCA patients
- Participants
- 470,960 participants
- Exposure
- Clonal hematopoiesis vs no clonal hematopoiesis
- Outcome
- Incident GCA
Methodological detailsUK Biobank exome sequencing, multivariable Cox regression, electronic health record review
- UK Biobank exome sequencing
- Multivariable Cox regression
- Electronic health record review
Main finding
As reported in the abstract
Fold increased risk
1.48
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Incident GCA, individuals with cytopenia | HR 2.98 | P = 0.00178 |
| Incident GCA, TET2 mutation | HR 2.02 | P = 0.00116 |
| Vision loss in GCA, TET2 mutations | OR 4.33 | P = 0.047 |
Mutations detected in institutional GCA cohort
- Mutations detected
- 27.2%
- HM at GCA diagnosis among those with mutations
- 3
Original publication
Association of Somatic TET2 Mutations With Giant Cell Arteritis. Arthritis Rheumatol. Published 2 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →