Vasculitis & polymyalgia rheumatica
Clonal haematopoiesis of indeterminate potential and relapses in patients with GCA
Main finding · GCA relapse at month 12, baseline factors (multivariate analysis)Result — go to the resultOdds ratio 9.94 95% CI 2.98–33.17Authors' conclusion
The presence of CHIP is associated with GCA relapses in this exploratory cohort.
Study context
- Population
- Recently diagnosed GCA patients, monocentric cohort; 20 women (50%), median age 73 years [67–80]
- Participants
- 40 participants
- Exposure
- Clonal haematopoiesis of indeterminate potential (CHIP) vs no CHIP
- CHIPn = 18
- Outcome
- Relapse (GCA-related signs or symptoms and/or inflammatory syndrome attributable to GCA after remission induction) within 12 months of GCA induction treatment
- Follow-up
- 12 months
Methodological detailsmonocentric, exploratory
- Monocentric
- Exploratory
Main finding
As reported in the abstract
GCA relapse at month 12, baseline factors (multivariate analysis)
Odds ratio
9.94
95% CI 2.98–33.17
P = 0.0002
CHIPvs No CHIP
OR 9.94 (95% CI 2.98–33.17); P = 0.0002
- Patients relapsed at 12 months (overall)
- 17 (42%)
- Ophthalmologic involvement at diagnosis, OR
- 4.02 (1.19-13.56), P < 0.025 (95% CI)
Observational data: associations, not effects.
Original publication
Clonal haematopoiesis of indeterminate potential and relapses in patients with GCA. Rheumatology (Oxford). Published 16 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →