Vasculitis & polymyalgia rheumatica
Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease
Authors' conclusion
Although BD patients did not have higher CHIP emergence rates than the general population, older age and degree of inflammation in BD were associated with CHIP emergence.
Study context
- Population
- Behçet's disease (BD) patients and healthy controls, March 2009 to September 2021
- Participants
- 117 vs 5,004
- Exposure
- BD patients vs healthy controls
- BDn = 117
- Controln = 5,004reference
- Outcome
- CHIP emergence rate
Methodological detailstargeted next-generation sequencing
- Targeted next-generation sequencing
Main finding
As reported in the abstract
CHIP detected
Observational data: associations, not effects.
Further findings
Clonal haematopoiesis of indeterminate potential (CHIP) variants in BD
- Five variants (DNMT3A, TET2, ASXL1, STAG2, IDH2) detected; DNMT3A most common, then TET2
Inflammatory markers in CHIP carriers vs non-carriers with BD · at diagnosis
- CHIP carriers had higher platelet count, ESR and CRP, older age and lower albumin
- Association between inflammatory markers and CHIP disappeared after adjustment, including age
Clinical outcomes in BD
- CHIP not an independent risk factor for poor clinical outcomes
Original publication
Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Behçet’s disease. Arthritis Res Ther. Published 2 March 2023. doi:10.
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