Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis
Authors' conclusion
Although synovitis increases during OA, our findings suggest that exhaustion, dysfunction, and loss of immune-regulatory macrophages is associated with worse pain
Study context
- Population
- Patients with mild-to-severe knee osteoarthritis (OA) pain (KOOS)
- Participants
- 122 synovial biopsies
- Outcome
- Synovial innate immune cell subsets and pathophysiologic mechanisms associated with worse pain
Methodological detailssynovial tissue biopsies, spatial transcriptomics and proteomics, single-cell RNA sequencing
- Synovial tissue biopsies
- Spatial transcriptomics and proteomics
- Single-cell RNA sequencing
Main finding
As reported in the abstract
Associations with worse pain
Synovial microvascular dysfunction and perivascular edema associated with worse KOOS pain
−10.76
95% CI −18.90 to −2.61
Synovial macrophages from patients with worse pain: decreased phagocytic function
−19.42%
95% CI −35.96 to −2.89
Original publication
Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis. Arthritis Rheumatol. Published 26 January 2025. doi:10.
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