Lupus & antiphospholipid syndrome
Association of STAT3 gene polymorphisms with systemic lupus erythematosus in a Chinese Han population
Authors' conclusion
STAT3 gene polymorphisms associated with SLE susceptibility.
Study context
- Population
- SLE patients and healthy controls, Chinese Han population
- Participants
- 300 vs 380
- Comparison
- SLE patients vs healthy controls
- SLEn = 300
- Healthy controlsn = 380reference
- Outcome
- Association of STAT3 gene polymorphisms (rs6503695, rs744166, rs9912773, rs12601982) with SLE susceptibility
Methodological detailsgenetic association study, Kompetitive Allele-Specific PCR (KASP) genotyping
- Genetic association study
- KASP genotyping
Main finding
As reported in the abstract
STAT3 genotype frequencies, SLE vs healthy controls
- rs6503695 genotypes CT, TT and TT+CT significantly lower in SLE vs healthy controls
- p = .007, p < .001, p = .001
- rs744166 genotypes AG, AA and AA+AG decreased in SLE vs healthy controls
- p = .034, p = .006, p = .009
- Recessive models (CC vs GG+GC) for rs9912773 and (AA vs GG+GA) for rs12601982 significantly related to SLE
- p = .014, p = .035
Observational data: associations, not effects.
Further findings
Clinical features in SLE patients by STAT3 genotype/allele
- rs6503695 allele C related to optic nerve damage
- P = 0.036
- rs744166 allele G correlated with positive rash and albuminuria
- P = 0.006, p = .014
- rs9912773 genotype GG: higher serum C3 and C4 vs GC+CC
- P = 0.029, p = .028
- rs12601982 allele G associated with positive hypocomplementemia
- P = 0.034
- rs12601982 genotypes GG, GC, CC had different SLEDAI score (GG vs GC vs CC)
- P = 0.003
Original publication
Association of STAT3 gene polymorphisms with systemic lupus erythematosus in a Chinese Han population. Lupus. Published 8 September 2023. doi:10.
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