Lupus & antiphospholipid syndrome
Genotype-guided new approach for dose optimisation of hydroxychloroquine administration in Chinese patients with SLE
Authors' conclusion
Our results suggest that the optimal blood concentration of HCQ measured approximately 12-18 hours after the last dosage may be between 500 and 600 ng/mL in Chinese patients with SLE. The observed variations in HCQ concentrations between individuals can potentially be attributed to genetic polymorphisms in CYP2D6*10 (rs1065852) and CYP2C8 (rs7910936 and rs10882521).
Study context
- Population
- Chinese patients with SLE taking hydroxychloroquine (HCQ) for more than 3 months
- Participants
- 489 patients
- Exposure
- Genotypes of CYP2C8 and CYP2D6*10 polymorphisms and blood HCQ concentrations
- Outcome
- Impact of gene polymorphisms on blood HCQ concentrations; optimal blood HCQ concentration by ROC
Methodological detailsROC curve analysis, SNP genotyping
- ROC curve analysis
- SNP genotyping
Main finding
As reported in the abstract
Cut-off value of HCQ (ng/mL)
559.67
Sensitivity of cut-off
0.51
Specificity of cut-off
0.89
Observational data: associations, not effects.
Further findings
Achieving optimal blood concentration, HCQ 200 mg/day (subgroup)
- CYP2C8 (rs7910936) CC genotype more likely to achieve optimal blood concentration
- P = 0.030
Achieving optimal blood concentration, HCQ 400 mg/day (subgroup)
- CYP2D6*10 (rs1065852) GG genotype more likely to reach optimal blood concentration
- P = 0.049
Original publication
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