Lupus & antiphospholipid syndrome
Association of GPX4 rs713041 and rs4807542 polymorphisms and serum GPX4 levels in Chinese patients with systemic lupus erythematosus
Authors' conclusion
In addition, GPX4 polymorphisms rs713041 and rs4807542 were independently associated with SLE susceptibility, whereas only rs713041 was independently associated with renal involvement in patients with SLE.
Study context
- Population
- Chinese patients with systemic lupus erythematosus (SLE), with and without lupus nephritis (LN), and healthy controlsgenotyping: 104 SLE, 100 controls
- Participants
- 28 / 28 / 28
- Comparison
- SLE vs healthy controls; LN vs non-LN
- LNn = 28
- Non-LNn = 28
- Healthy controlsn = 28reference
- Outcome
- Serum GPX4 levels (enzyme-linked immunosorbent assay (ELISA)) and GPX4 rs713041 and rs4807542 polymorphisms in association with SLE and LN
Methodological detailshospital-based, multivariable binary logistic regression
- Hospital-based
- Multivariable binary logistic regression
Main finding
As reported in the abstract
Serum GPX4 levels
- Serum GPX4 significantly lower in both LN and non-LN groups than in healthy controls
- GPX4 showed moderate diagnostic accuracy for SLE detection
Observational data: associations, not effects.
Further findings
SLE susceptibility, GPX4 polymorphisms
- Univariate: rs713041 CC genotype and C allele, rs4807542 GA genotype and A allele carriers had significantly increased risk of SLE vs healthy controls
- rs713041 CC genotype and rs4807542 A-carrier status independently associated with SLE susceptibility after adjustment for age and sex
LN vs non-LN, GPX4 polymorphisms
- Univariate: rs713041 CC genotype and C allele carriers significantly associated with increased risk of LN
- rs713041 CC genotype independently associated with renal involvement after adjustment for age, sex, disease duration and SLEDAI score
Original publication
Association of GPX4 rs713041 and rs4807542 polymorphisms and serum GPX4 levels in Chinese patients with systemic lupus erythematosus. Lupus. Published 2 July 2026. doi:10.
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