Lupus & antiphospholipid syndrome
Defining the physician global assessment threshold equivalent to remission in patients with systemic lupus erythematosus
Authors' conclusion
Using a PGA threshold of <2 (0-10), corresponding to <0.6 (0-3), resulted in best prediction of physician remission.
Study context
- Population
- Patients with SLE in a single-centre lupus cohort
- Participants
- 233 patients
- Outcome
- Ideal PGA threshold associated with physician remission
Methodological detailsmonocentric, ROC analysis, regression analyses
- Monocentric
- ROC analysis
- Regression analyses
Main finding
As reported in the abstract
PGA threshold for physician remission
| Group | Sensitivity | Specificity | AUC (physician remission) | AUC (modDORIS) |
|---|---|---|---|---|
| Physician global assessment (PGA) <2 | 79% | 81% | 0.85 | 0.69 |
Physician global assessment (PGA) <2
Sensitivity79%
Specificity81%
AUC (physician remission)0.85
AUC (modDORIS)0.69
Observational data: associations, not effects.
Further findings
Remission rates
- Physician remission
- 126 patients (54.0%)
- DORIS remission
- 42.5%
- modDORIS remission
- 67.0%
Factors associated with PGA
- PGA in patients fulfilling any remission definition associated with pain and hypocomplementemia
- Damage numerically higher in modDORIS only; no association between PGA and damage in regression analysis
Original publication
Defining the physician global assessment threshold equivalent to remission in patients with systemic lupus erythematosus. Rheumatology (Oxford). Published 7 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →