Lupus & antiphospholipid syndrome
Association of phenotypic frailty and hand grip strength with telomere length in SLE
Authors' conclusion
Decreased hand grip strength, but not frailty, was independently associated with shortened telomere length in a cohort of non-elderly women with SLE.
Study context
- Population
- Women ≥18 years with validated SLE, single medical centre131 with frailty classification
- Participants
- 150 women
- Exposure
- Frail vs non-frail women with SLE; hand grip strength and telomere length
- Outcome
- Difference in telomere length between frail and non-frail women with SLE
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Telomere length, frail vs non-frail
Frail (proportion of participants)
26%
Observational data: associations, not effects.
Further findings
Hand grip strength and telomere length (linear regression)
- Beta coefficient, unadjusted
- 0.02 (95% CI 0.004, 0.04)
- Beta coefficient, adjusted for age, SLE disease activity, organ damage and comorbidity
- 0.02 (95% CI 0.002, 0.04)
Original publication
Association of phenotypic frailty and hand grip strength with telomere length in SLE. Lupus Sci Med. Published 22 March 2024. doi:10.
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