Lupus & antiphospholipid syndrome
Social support and depression status are risk factors of frailty in systemic lupus erythematosus patients: multicentre retrospective analysis using the Systemic Lupus Erythematosus International Collaborating Clinics-Frailty Index
Authors' conclusion
Age, SDI score, and depression status were risk factors for frailty in patients with SLE. In addition, lower social support scores were associated with increases of depression status and frailty in patients with SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) from five tertiary hospitals in Korea
- Outcome
- Frailty (SLICC-FI) and its risk factors
Methodological detailsmulticentre, multivariable logistic regression, simple linear regression
- Multicentre
- Multivariable logistic regression
- Simple linear regression
Main finding
As reported in the abstract
Frailty (SLICC-FI)
Odds ratio (95% CI)P value
Age
1.054(1.013–1.097)
P = 0.009SDI score
2.995(1.940–4.622)
P < 0.001PHQ-9 ≥10
7.884(2.785–22.319)
P < 0.001- Classified as frail
- 36 (14.6%)
Observational data: associations, not effects.
Further findings
SLICC-FI vs Multidimensional Scale of Perceived Social Support (MSPSS) (simple linear regression)
- Negative correlation, R2
- 0.06, p≤0.001
SLICC-FI vs PHQ-9K (simple linear regression)
- Positive correlation, R2
- 0.276, p<0.001
MSPSS vs PHQ-9K (simple linear regression)
- Negative correlation, R2
- 0.147, p<0.001
Original publication
Social support and depression status are risk factors of frailty in systemic lupus erythematosus patients: multicentre retrospective analysis using the Systemic Lupus Erythematosus International Collaborating Clinics-Frailty Index. Clin Exp Rheumatol. Published 11 November 2025. doi:10.
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