Association Between Discordance of Disease Activity Indices and Quantitative Sensory Testing Measures of Nociplastic Pain in Patients With Rheumatoid Arthritis
Authors' conclusion
Two of our proposed measures of discordance (higher TSJD and DAS28-P) were modestly associated with worse QST measures of nociplastic pain (lower trapezius PPT and higher TS), suggesting that discordance between patient-reported and physician-assessed measures of disease activity may reflect an element of nociplastic pain.
Study context
- Population
- Patients with active rheumatoid arthritis (RA)
- Participants
- 225 patients
- Outcome
- Association between measures of discordance in disease activity (TSJD, DAS28-P, PtGA - EGA) and QST measures (trapezius PPT, TS, conditioned pain modulation)
Methodological detailsunadjusted and multivariable linear regression
- Unadjusted and multivariable linear regression
Main finding
As reported in the abstract
Higher TSJD with lower trapezius PPT, β
−0.05 (−0.08 to −0.02) (95% CI)
Higher TSJD with higher temporal summation (TS), β
0.29 (0.05 to 0.53) (95% CI)
Higher DAS28-P with lower trapezius PPT, β
−0.05 (−0.07 to −0.04) (95% CI)
Higher DAS28-P with higher TS, β
0.21 (0.06 to 0.35) (95% CI)
Observational data: associations, not effects.
Further findings
Discordance measures, descriptive
- Mean TSJD (SD)
- 5.4 (±8.2)
- Mean DAS28-P (SD)
- 49.7% (±13.3%)
- Mean PtGA - EGA (SD)
- 0.7 (±2.2)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →