Elevated DAS28, CDAI, RAPID3 and five of seven rheumatoid arthritis (RA) core data set measures in patients with positive screens for anxiety, depression or fibromyalgia on an MDHAQ
Authors' conclusion
Five RA indices and five of seven individual core data set measures are elevated significantly in patients who screen positive for anxiety, depression and/or fibromyalgia on MDHAQ indices.
Study context
- Population
- Routine care patients with RA
- Participants
- 173 patients
- Exposure
- Patients with positive vs negative MDHAQ distress screens
- Outcome
- Associations of MDHAQ distress screens with RA activity/severity indices (DAS28-ESR, DAS28-CRP, SDAI, CDAI, RAPID3) and the seven RA core data set measures
Methodological detailsroutine care database, t tests and chi2 tests
- Routine care database
- T tests and chi2 tests
Main finding
As reported in the abstract
Positive screening prevalence
- Positive MAS2
- 37%
- Positive MDS2
- 27%
- Positive FAST3F
- 31%
- Positive for at least one of the three screens
- 45%
- All five RA indices and five of seven core data set measures (other than swollen joint count (SJC), ESR and CRP) elevated significantly in MAS2, MDS2 and/or FAST3F positive patients, generally to a higher activity/severity category
- P-value < 0.01
Observational data: associations, not effects.
Further findings
Patients with 0 or 1 SJC but moderate/high RA index activity/severity (27-41% of all patients)
- Positive MDHAQ anxiety, depression and/or fibromyalgia screen
- 54-100%
Original publication
Elevated DAS28, CDAI, RAPID3 and five of seven RA core data set measures in patients with positive screens for anxiety, depression or fibromyalgia on an MDHAQ. Rheumatology (Oxford). Published 28 March 2025. doi:10.
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