Minimally invasive retrieval and characterisation of tenosynovial tissue in rheumatoid arthritis: a novel approach to study at-risk, active, and remission stages
Authors' conclusion
Tenosynovium is frequently inflamed and readily accessible in CSA and RA.
Study context
- Population
- Patients with preclinical (autoantibody-positive clinical suspect arthralgia (CSA)) and clinical rheumatoid arthritis (RA), healthy controls; biopsy cohort with CSA, RA and osteoarthritis (OA) patients
- Participants
- 834 magnetic resonance imaging (MRI) wrist scans
- Comparison
- Autoantibody-positive CSA and RA vs healthy controls and OA controls
- CSAn = 168
- RAn = 473
- Healthy controlsn = 193reference
- Outcome
- Rate of MRI-detected extensor/flexor tendon tenosynovitis in the wrists
Methodological detailsultrasound-guided minimally invasive biopsy, MRI cohort and independent biopsy cohort
- Ultrasound-guided minimally invasive biopsy
- MRI cohort and independent biopsy cohort
Main finding
As reported in the abstract
MRI-detected tenosynovitis of wrist extensor/flexor tendons
Further findings
Successful US-guided tenosynovium retrieval (biopsy cohort: 16 CSA, 41 RA, 8 OA)
- Tenosynovium successfully retrieved
- 89.7%
Tenosynovial lining hyperplasia and inflammatory infiltrate
- Significantly higher in active RA than CSA without US-detected subclinical inflammation and RA remission; comparable to inflamed adjacent synovium
Tenosynovial cell composition in CSA with subclinical inflammation
- Early CD3pos and CD55pos cell enrichment vs OA controls
Safety
Severe adverse events of tenosynovial biopsy
- No severe adverse events
Original publication
Minimally invasive retrieval and characterisation of tenosynovial tissue in rheumatoid arthritis: a novel approach to study at-risk, active, and remission stages. Ann Rheum Dis. Published 27 March 2025. doi:10.
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