Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain
Authors' conclusion
In individuals with clinically active RA, markers of inflammatory disease activity best explain RA pain with only marginal contributions from QST indices of central sensitisation.
Study context
- Population
- Individuals with clinically active rheumatoid arthritis (RA) (age 65 ± 10y, 77% females)
- Participants
- 96 individuals
- Outcome
- Proportion of RA pain severity (NRS) explained by markers of inflammation (Disease Activity Score (DAS28), US greyscale and power Doppler) and QST indices of central sensitisation (PPT-TA/PPT-BR, TS, CPM)
Main finding
As reported in the abstract
Associations with pain severity
Bivariate: pain severity vs inflammation indices, r
0.20 to 0.55
Bivariate: pain severity vs CPM, r
−0.26
Pain variance explained by multivariable models
22 to 27%
Observational data: associations, not effects.
Further findings
Pain subscores (pain now, strongest, average over past 4 weeks)
- Heterogeneity apparent for associations with pain between subscores
Original publication
Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain. Arthritis Res Ther. Published 8 October 2024. doi:10.
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