Systemic sclerosis & Raynaud's
Anti-Th/To antibodies in systemic sclerosis: analysis of long-term follow-up of pulmonary involvement, organ damage accrual and mortality in an Italian cohort with a case-control study
Authors' conclusion
In this study, anti-Th/To+ patients showed a mild SSc phenotype, characterised by low organ damage, favourable ILD outcome and good survival.
Study context
- Population
- Systemic sclerosis (SSc) patients, Italian single-centre cohort13 anti-Th/To+ cases
- Comparison
- Anti-Th/To+ SSc vs anti-topo 1+, ACA+ and quadruple-negative SSc
- Anti-Th/To+n = 13
- Outcome
- ILD
Methodological detailssingle-centre, matched (1:3) for sex and age at SSc onset
- Single-centre
- Matched (1:3) for sex and age at SSc onset
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Anti-Th/To+ | Anti-topo 1+ | Quadruple-negative |
|---|---|---|---|
| ILD requiring immunosuppression | 8% | 41% | 44% |
- Functional worsening of interstitial lung disease (ILD), anti-Th/To+ · 5 years
- 15.4%
Functional worsening of ILD, anti-Th/To+ · 5 years
- No long-term complications (no need for O2, pulmonary hypertension, death)
SCTC-Damage Index
- Lower in anti-Th/To+ than anti-topo 1+ and quadruple-negative at various timepoints; remained low during long-term follow-up (median 16 years)
Survival, anti-Th/To+ · 5 and 10 years
- 5-year survival
- 92%
- 10-year survival
- 72%
- Did not differ from matched SSc patients; none died due to SSc, mortality mainly cancer-related
Clinical features of anti-Th/To+
- Limited cutaneous involvement
- 100%
- Digital ulcers
- 46%
- Pulmonary arterial hypertension (PAH), synovitis, joint contractures
- 0
Original publication
Anti-Th/To antibodies in systemic sclerosis: analysis of long-term follow-up of pulmonary involvement, organ damage accrual and mortality in an Italian cohort with a case-control study. Clin Exp Rheumatol. Published 23 July 2022. doi:10.
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