Systemic sclerosis & Raynaud's
Late skin fibrosis in systemic sclerosis: a study from the EUSTAR cohort
Authors' conclusion
Late skin fibrosis is not uncommon in SSc.
Study context
- Population
- Patients with systemic sclerosis (SSc) in the EUSTAR database with complete modified Rodnan skin score (mRSS); late skin fibrosis defined as >5 years after first non-RP featureout of 19,115 in database
- Participants
- 1,043 patients
- Outcome
- Prevalence and characteristics of late skin fibrosis (mRSS worsening ≥5 units or ≥25%)
- Follow-up
- >5 years after first non-RP feature
Methodological detailsEUSTAR database, multicentre
- EUSTAR database
- Multicentre
Main finding
As reported in the abstract
Late mRSS worsening
mRSS worsening, whole cohort
n = 208/1043, 19.9%
mRSS worsening, lcSSc or dcSSc at baseline
n = 193/887, 21.8%
Observational data: associations, not effects.
Further findings
Characteristics of late skin fibrosis
- Largely due to new skin worsening after the 5-year window or failure to improve with worsening within the 5-year window
- Lower baseline mRSS and lcSSc more likely to develop late skin fibrosis
- Anti-Scl-70 associated with progression from baseline lcSSc to dcSSc; anticentromere protective
Original publication
Late skin fibrosis in systemic sclerosis: a study from the EUSTAR cohort. Rheumatology (Oxford). Published 22 June 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →