Lupus & antiphospholipid syndrome
Anti-SSB antibodies promotes interleukin-6 production in monocytes through a toll-like receptor4-dependent way in systemic lupus erythematosus
Authors' conclusion
Our findings demonstrate that anti-SSB antibodies promote cytokine production, particularly IL-6, in monocytes through a TLR4-dependent mechanism.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients and healthy controls; Peripheral blood mononuclear cells (PBMCs)
- Participants
- 31 vs 35
- Comparison
- SLE vs Healthy controls
- SLEn = 31
- Healthy controlsn = 35reference
- Outcome
- Effects of autoantibodies on PBMCs in SLE
Main finding
As reported in the abstract
Antibodies targeting a 55-kDa autoantigen detected in SLE patients
48.8%
Anti-SSB antibodies promoted mRNA expression of TNF-α, IL-1β, IL-4 and IL-6 in PBMCs; IL-6 increase (p<0.001)
more than 100-fold
Original publication
Anti-SSB antibodies promotes interleukin-6 production in monocytes through a toll-like receptor4-dependent way in systemic lupus erythematosus. Clin Exp Rheumatol. Published 12 February 2025. doi:10.
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