Lupus & antiphospholipid syndrome
Anifrolumab induces a fast improvement in ultrasound-detected synovitis in systemic lupus erythematosus: Results from a 6-months follow-up ultrasound study
Authors' conclusion
Our analysis, made in a real-life scenario, underlines the fast efficacy of ANF on joint synovitis as shown by the reduction in US scores in the early stages of treatment.
Study context
- Population
- Female Systemic Lupus Erythematosus (SLE) patients receiving anifrolumab for musculoskeletal manifestationsall female
- Participants
- 13 patients
- Outcome
- US inflammatory features (synovial effusion/hypertrophy, Power Doppler) at bilateral hand MCP and PIP joints per OMERACT: total US inflammatory score (0-180) and total PD score (0-60)
- Follow-up
- 1, 3 and 6 months
Methodological detailsreal-life, single-group, 6-month follow-up
- Real-life
- Single-group
- 6-month follow-up
Main finding
As reported in the abstract
US scores
Negativization of pD signal in all joints after 6 months
90%
Observational data: associations, not effects.
Further findings
Global disease activity indices and DAS28-CRP · all time-points
- Significant improvement at all time-points
Original publication
Anifrolumab induces a fast improvement in ultrasound-detected synovitis in systemic lupus erythematosus: Results from a 6-months follow-up ultrasound study. Lupus. Published 8 July 2026. doi:10.
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