Spondyloarthritis & psoriatic arthritis
An Immunosenescent CD8 + T Cell Subset in Patients with Axial Spondyloarthritis and Psoriatic Arthritis Links Spontaneous Motility to Telomere Shortening and Dysfunction
Authors' conclusion
These data describe a terminally differentiated CD8+ T cell subset with a senescent and cytotoxic/proinflammatory profile and an intrinsic invasive potential enriched in patients with SpA that represents a possible player in disease pathogenesis.
Study context
- Population
- Peripheral blood CD8+ and CD4+ T cells from patients with radiographic axial spondyloarthritis (r-axSpA), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) and healthy donors
- Participants
- 128 / 60 / 74 / 79
- Comparison
- Patients with r-axSpA and PsA vs patients with RA and healthy donors
- r-axSpAn = 128
- PsAn = 60
- RAn = 74
- Healthy donors (HDs)n = 79reference
- Outcome
- Migration of CD8+ T cells, with their phenotype and functions
Methodological detailsTranswell migration assay, multiparametric flow cytometry, RNA sequencing
- Transwell migration assay
- Multiparametric flow cytometry
- RNA sequencing
Main finding
As reported in the abstract
Spontaneously migrating CD8+ T cells (no chemokine stimuli)
- Significantly higher number of CD8+ T cells migrating without chemokine stimuli in spondyloarthritis (SpA) vs HDs and RA
- Subset produces cytotoxic (granzyme B, perforin, granulysin) and proinflammatory (TNF) molecules
- Significantly enriched in terminally differentiated (CCR7-CD45RA+) and senescent (CD28-CD57+) cells, with cytolytic signature and natural killer markers
- DNA damage response activation, telomere shortening and dysfunction
Original publication
An Immunosenescent CD8 + T Cell Subset in Patients with Axial Spondyloarthritis and Psoriatic Arthritis Links Spontaneous Motility to Telomere Shortening and Dysfunction. Arthritis Rheumatol. Published 18 February 2025. doi:10.
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