Spondyloarthritis & psoriatic arthritis
Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis
Authors' conclusion
axSpA and PsA share overlapping yet distinguishable immunophenotypic signatures. axSpA shows enrichment of innate-associated and broadly activated immune features, whereas PsA is characterized by adaptive and memory-associated immune responses.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) and healthy donors; PBMC immunophenotyping179 patients
- Participants
- 88 / 91 / 49
- Exposure
- axSpA vs PsA
- axSpAn = 88
- PsAn = 91
- Healthy donorsn = 49reference
- Outcome
- Immune signatures distinguishing axSpA from PsA
Methodological detailsspectral flow cytometry, regularized regression
- Spectral flow cytometry
- Regularized regression
Main finding
As reported in the abstract
Immune signature distinguishing axSpA from PsA, cross-validated AUC
0.94
Observational data: associations, not effects.
Original publication
Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis. Arthritis Rheumatol. Published 6 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →