Fibromyalgia & musculoskeletal pain
Altered whole brain functional activity in patients with fibromyalgia
Authors' conclusion
This study demonstrates abnormal brain activation which could lead to increased sensitivity of pain in patients with FM.
Study context
- Population
- fMRI studies of patients with fibromyalgia (FM), PubMed and Web of Science, from inception until September 1st, 202226 FM publications
- Participants
- 1,056 participants
- Comparison
- Patients with FM vs healthy individuals
- Outcome
- Abnormal brain function (activation) in FM
Methodological detailsActivation Likelihood Estimation (ALE) analysis, Two separate researchers assessed the bias and quality of the studies
- Activation Likelihood Estimation (ALE) analysis
- Two separate researchers assessed the bias and quality of the studies
Pooled result
As reported in the abstract
Abnormal brain activation in FM (ALE analysis)
Z-values
4.46 and 4.97
P-values
4.06 and 3.38
Further pooled results
Correlation of degree of pain with insula activation
- Negative correlation, SDM-Z
- −2.714
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Altered whole brain functional activity in patients with fibromyalgia. Clin Exp Rheumatol. Published 3 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →