Fibromyalgia & musculoskeletal pain

Fibromyalgia and mortality: a systematic review and meta-analysis

RMD OpenPublished Systematic review and meta-analysis

Study context

Population
Original papers assessing associations between fibromyalgia and mortality (all or specific causes) with an effect measure (HR, standardised mortality ratio (SMR), OR); PubMed, Scopus, Web of Science8 papers
Participants
188,751 participants
Comparison
FM vs no FM
  • FMn = 188,751
Outcome
All-cause mortality
Methodological detailsNewcastle-Ottawa scale risk-of-bias assessment
  • Newcastle-Ottawa scale risk-of-bias assessment

Pooled result

As reported in the abstract

All-cause mortality in fibromyalgia

Increased HR for all-cause mortality

HR 1.27, 95% CI 1.04 to 1.51

Further pooled results

All-cause mortality, subgroup diagnosed by the 1990 criteria

No increased HR for the subgroup diagnosed by the 1990 criteria

Mortality from accidents

Borderline increased SMR for accidents
SMR 1.95, 95% CI 0.97 to 3.92

Mortality from infections

Increased risk for mortality from infections
SMR 1.66, 95% CI 1.15 to 2.38

Mortality from suicide

Increased risk for mortality from suicide
SMR 3.37, 95% CI 1.52 to 7.50

Mortality from cancer

Decreased mortality rate for cancer
SMR 0.82, 95% CI 0.69 to 0.97

Original publication

Fibromyalgia and mortality: a systematic review and meta-analysis. RMD Open. Published 10 July 2023. doi:10.1136/rmdopen-2023-003005

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