Fibromyalgia & musculoskeletal pain
Association of catechol-O-methyltransferase Val158Met polymorphism with fibromyalgia risk and FIQ scores: an updated meta-analysis
Pooled result · FM risk, COMT Met allele (all study subjects)Result — go to the resultOdds ratio 1.375 95% CI 1.076–1.757Authors' conclusion
This meta-analysis indicates significant associations of COMT Val158Met polymorphism with both FM risk and FIQ score in FM patients.
Study context
- Population
- Patients with fibromyalgia (FM) and controls in studies of catechol-O-methyltransferase (COMT) Val158Met polymorphism (Medline, Embase, Web of Science)16 studies
- Participants
- 2,115 vs 1,867
- Comparison
- COMT Met allele vs Val allele; Met/Met vs Val/Val and Val/Met genotypes
- FMn = 2,115
- Controlsn = 1,867reference
- Outcome
- Association of COMT Val158Met polymorphism with FM risk and FIQ score
Methodological detailsupdated meta-analysis, regional stratification, recessive, dominant and homozygote contrast models
- Updated meta-analysis
- Regional stratification
- Recessive, dominant and homozygote contrast models
Pooled result
FM risk, COMT Met allele (all study subjects)
Odds ratio
1.375
95% CI 1.076–1.757
P = 0.001
COMT Met allele
OR 1.375 (95% CI 1.076–1.757); P = 0.001
As reported in the abstract
Further pooled results
| Outcome | WMD (95% CI) | P value | |
|---|---|---|---|
| FIQ score by COMT genotype (8 studies, 1,199 FM patients)Met/Metvs Val/Val | 11.24 (4.742–17.74) | P = 0.001 | |
| FIQ score by COMT genotype (8 studies, 1,199 FM patients)Met/Metvs Val/Met | 5.950 (2.017–9.893) | P = 0.003 | |
| −1001020Difference (linear scale) |
FM risk, COMT Met allele, by region (European, Latin American, Asian)
- No association in European, Latin American, or Asian populations; same pattern with recessive, dominant and homozygote contrast models
Original publication
Association of catechol-O-methyltransferase Val158Met polymorphism with fibromyalgia risk and FIQ scores: an updated meta-analysis. Clin Exp Rheumatol. Published 28 September 2024. doi:10.
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