Lupus & antiphospholipid syndrome
Air Pollution, Genetic Susceptibility, and Risk of Incident Systemic Lupus Erythematosus: A Prospective Cohort Study
Authors' conclusion
Long-term exposure to air pollutants (PM2.5, PM10, NO2, and NOx) may increase the risk of developing SLE.
Study context
- Population
- UK Biobank participants399 incident systemic lupus erythematosus (SLE)
- Participants
- 459,815 participants
- Exposure
- Long-term exposure to air pollutants (PM2.5, PM10, NO2, NOx), per IQR increase; joint effects with genetic risk
- Outcome
- Incident SLE
Methodological detailsUK Biobank, land-use regression model, Cox proportional hazards model, polygenic risk score
- UK Biobank
- Land-use regression model
- Cox proportional hazards model
- Polygenic risk score
Main finding
As reported in the abstract
Incident SLE per IQR increase in air pollutant · median follow-up 11.77 years
Adjusted hazard ratio (95% CI)
PM2.5 (per IQR increase)
1.18(1.06–1.32)
PM10 (per IQR increase)
1.23(1.10–1.39)
NO2 (per IQR increase)
1.27(1.14–1.41)
NOx (per IQR increase)
1.13(1.03–1.23)
Per IQR increase, as printed
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Incident SLE, joint effect of high genetic risk and high air pollution exposureHigh genetic risk and high air pollution exposurevs Low genetic risk and low air pollution exposure | aHR (PM2.5) 4.16 (95% CI 2.67–6.49) | |
| Incident SLE, joint effect of high genetic risk and high air pollution exposureHigh genetic risk and high air pollution exposurevs Low genetic risk and low air pollution exposure | aHR (PM10) 5.31 (95% CI 3.30,–8.55) | |
| Incident SLE, joint effect of high genetic risk and high air pollution exposureHigh genetic risk and high air pollution exposurevs Low genetic risk and low air pollution exposure | aHR (NO2) 5.61 (95% CI 3.45–9.13) | |
| Incident SLE, joint effect of high genetic risk and high air pollution exposureHigh genetic risk and high air pollution exposurevs Low genetic risk and low air pollution exposure | aHR (NOx) 4.80 (95% CI 3.00–7.66) | |
| 0.10.31310Ratio (log scale) |
Interaction between NO2 and polygenic risk score (PRS)
- Significant multiplicative interaction between NO2 and PRS
Original publication
Air Pollution, Genetic Susceptibility, and Risk of Incident Systemic Lupus Erythematosus: A Prospective Cohort Study. Arthritis Rheumatol. Published 10 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →