Lupus & antiphospholipid syndrome
Fine Particulate Matter Constituents, Ozone, and Systemic Lupus Erythematosus: A Large General‐Population Cohort Analysis With Extended Quantile g‐Computation
Authors' conclusion
This study demonstrated how PM2.5 constituents (especially mineral dust) and ozone are associated with SLE incidence.
Study context
- Population
- Adults with ≥2 years' insurance coverage and no prior systemic lupus erythematosus (SLE) diagnosis (MarketScan claims data)21,485 incident SLE
- Participants
- 8.3 million adults
- Exposure
- Per-quartile increase in PM2.5 constituent mixture and per 1 ppb ozone
- Outcome
- Incident SLE
Methodological detailsclaims-based (MarketScan), 20% random sample case-cohort, extended quantile g-computation, adjusted for sex, age, COPD, geographic region and calendar year
- Claims-based (MarketScan)
- 20% random sample case-cohort
- Extended quantile g-computation
- Adjusted for sex, age, COPD, geographic region and calendar year
Main finding
As reported in the abstract
Incident SLE per quartile increase of PM2.5 mixture, at median ozone (36.15 ppb)
HR per quartile increase of PM2.5 mixture
1.14
95% CI 1.11–1.18
Observational data: associations, not effects.
Further findings
Incident SLE per 1 ppb ozone
- HR per 1 ppb ozone
- 1.009 (95% CI 1.001-1.017)
PM2.5 effect by ozone level
- PM2.5's effect particularly strong in settings of low ozone
Original publication
Fine Particulate Matter Constituents, Ozone, and Systemic Lupus Erythematosus: A Large General‐Population Cohort Analysis With Extended Quantile g‐Computation. Arthritis Rheumatol. Published 3 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →