A Call for Gene Expression Analysis in Whole Blood of Patients With Rheumatoid Arthritis (RA) as a Biomarker for RA-Associated Interstitial Lung Disease
Authors' conclusion
All gene products of these genes (except for LINC02967) are known from the literature to be involved in the pathogenesis of fibrosis.
Study context
- Population
- Female patients with RA with or without interstitial lung disease (ILD)all female
- Participants
- 12 patients
- Comparison
- RA-ILD vs RA without ILD
- RA-ILDn = 7
- RAn = 5reference
- Outcome
- Differences in whole-blood gene expression patterns between RA-ILD and RA without ILD
Methodological detailsRNA-Seq of whole blood, differential gene expression analysis
- RNA-Seq of whole blood
- Differential gene expression analysis
Main finding
As reported in the abstract
Significantly upregulated genes in RA-ILD vs RA without ILD
- Significantly upregulated genes in RA-ILD vs RA without ILD: ARG1, thymidylate synthetase (TYMS), SORT1, MKI67, OLFM4, BIRC5, MS4A4A, CLEC12A, LINC02967
- 9
Original publication
A Call for Gene Expression Analysis in Whole Blood of Patients With Rheumatoid Arthritis (RA) as a Biomarker for RA-Associated Interstitial Lung Disease. J Rheumatol. Published 1 December 2023. doi:10.
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