A meta-analysis of the association between the ATIC 347 C/G polymorphism and methotrexate responsiveness and toxicity in rheumatoid arthritis
Pooled result · Failure to respond to MTXResult — go to the resultOdds ratio 0.741 95% CI 0.591–0.929Authors' conclusion
This meta-analysis revealed that ATIC 347 C/G polymorphism was related to non-responsiveness to MTX in European populations with RA. However, no significant correlation was found with MTX toxicity.
Study context
- Population
- Patients with rheumatoid arthritis (RA) treated with methotrexate (MTX)
- Participants
- 3,185 patients13 studies
- Comparison
- ATIC 347 GG genotype vs other genotypes
- Outcome
- MTX non-responsiveness and MTX toxicity
Methodological detailsstratification by ethnicity
- Stratification by ethnicity
Pooled result
Failure to respond to MTX
Odds ratio
0.741
95% CI 0.591–0.929
P = 0.009
ATIC 347 GG genotypevs other genotypes
OR 0.741 (95% CI 0.591–0.929); P = 0.009
As reported in the abstract
Further pooled results
MTX non-responsiveness by ethnicity (subgroups)
| OR (95% CI) | P value | ||
|---|---|---|---|
| ATIC 347 GGEuropeans | 0.548 (0.377–0.796) | P = 0.002 | |
| ATIC 347 GGAsian populations | 0.882 (0.665–1.1172) | P = 0.388 | |
| 0.20.5125Odds ratio (log scale) |
Safety
MTX toxicity
| OR (95% CI) | P value | ||
|---|---|---|---|
| ATIC 347 GG7 studies on MTX toxicity | 1.278 (0.937–1.745) | P = 0.121 | |
| 0.512Odds ratio (log scale) |
MTX toxicity by ethnicity (subgroups)
| OR (95% CI) | P value | ||
|---|---|---|---|
| ATIC 347 GGAsian | 1.252 (0.905–1.732) | P = 0.175 | |
| ATIC 347 GGEuropean | 1.617 (0.549–4.765) | P = 0.383 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
A meta-analysis of the association between the ATIC 347 C/G polymorphism and methotrexate responsiveness and toxicity in rheumatoid arthritis. Semin Arthritis Rheum. Published 30 November 2023. doi:10.
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