Genetically-determined variation in CRP impacts disease activity assessment in rheumatoid arthritis
Authors' conclusion
The rs1205 TT genotype in CRP is associated with lower CRP and DAS28(CRP).
Study context
- Population
- Patients from three observational cohorts: UK Biobank (United Kingdom Biobank (UKB)), Veterans Affairs RA Registry (VARA) and FORWARD Databank488,377 UKB
- Exposure
- rs1205 TT and CT genotypes vs CC genotype
- Outcome
- Effect of rs1205 genotype on log-adjusted serum CRP concentrations
Methodological detailslinear regression adjusted for sex, age and population structure
- Linear regression adjusted for sex, age and population structure
Main finding
As reported in the abstract
Log-adjusted CRP (UKB)
β
−0.371
95% CI −0.381 to −0.360P < 0.001
TT
β
−0.173
95% CI −0.179 to −0.167P < 0.001
CT
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) | P value |
|---|---|---|
| DAS28(CRP) (VARA)TT vs CC | −0.22 (−0.44 to −0.0027) | P = 0.047 |
DAS28(CRP) (VARA)
- Not significantly lower in CT vs CC genotype
Reclassification in TT genotype
- Reclassified to abnormal CRP (>0.8 mg/dl)
- 6-8%
- Reclassified from low to moderate disease activity
- 3%
Original publication
Genetically-determined variation in CRP impacts disease activity assessment in rheumatoid arthritis. Rheumatology (Oxford). Published 18 March 2025. doi:10.
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