Do MRI-detected erosions in the rheumatoid arthritis (RA)-risk phase of arthralgia reflect current or imminent radiographic erosions? A large longitudinal imaging study
Authors' conclusion
The majority of MRI-detected erosions in CSA patients does not correspond with radiographic erosive disease or progression.
Study context
- Population
- Patients with clinically suspect arthralgia (CSA) in the Leiden CSA cohort (2012–2021), followed until RA development or for 2 years
- Participants
- 405 patients
- Exposure
- MRI-detected erosions vs radiographic erosions and progression in the same bone
- Outcome
- (i) Correspondence of MRI-detected erosions with simultaneous radiographic erosions and (ii) association with local radiographic progression
Methodological detailslongitudinal imaging study, generalized estimating equations
- Longitudinal imaging study
- Generalized estimating equations
Main finding
As reported in the abstract
baseline
- CSA patients with MRI-detected erosions (≥1 of 23 bone locations)
- 190/405 (47%)
- Association of MRI-detected erosion with local radiographic erosion, OR
- 5.23 (2.78-9.86) (95% CI)
- Locations with MRI-detected erosion without radiographic erosion
- 96.5%
- Local radiographic progression
- 0.4%
- Baseline MRI erosions predicting radiographic progression, OR
- 1.75 (0.52-5.85) (95% CI)
Observational data: associations, not effects.
Further findings
MRI erosions with concomitant local subclinical inflammation and local radiographic erosion
- Association, OR
- 6.29 (2.94-13.48) (95% CI)
Original publication
Do MRI-detected erosions in the RA-risk phase of arthralgia reflect current or imminent radiographic erosions? A large longitudinal imaging study. Rheumatology (Oxford). Published 17 March 2025. doi:10.
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