Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis
Performance · Baseline pain, VARA validation data setResult — go to the resultDifference +0.55 95% CI 0.16–0.93Authors' conclusion
GRS based on pain-related SNPs were associated with RA pain and disease activity
Study context
- Population
- Participants with rheumatoid arthritis (RA) and pain and genotyping data from FORWARD (National Databank for Rheumatic Diseases; training) and the Veterans Affairs Rheumatoid Arthritis Registry (VARA; validation)756 FORWARD
- Comparison
- Highest vs lowest quartile of fibromyalgia (FM) genetic risk score (GRS) for pain
- Outcome
- Baseline pain by GRS for pain derived from 36 FM-associated single-nucleotide polymorphisms (SNPs) (validation data set, VARA)
- Follow-up
- Baseline
Methodological detailstwo independent cohorts, training and validation data sets, multivariable linear regression, generalized estimating equations
- Two independent cohorts
- Training and validation data sets
- Multivariable linear regression
- Generalized estimating equations
Performance
Baseline pain, VARA validation data set
Difference
+0.55
95% CI 0.16–0.93
P = 0.006
As reported in the abstract
Further findings
Baseline pain by existing pain intensity GRS (VARA)
- Highest quartile also had more baseline pain than lowest quartile
Pain throughout follow-up and disease activity, both GRS (VARA)
- Highest quartile of both GRS had more pain throughout follow-up and higher disease activity scores
Original publication
Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Published 11 September 2025. doi:10.
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