Vasculitis & polymyalgia rheumatica
Von Willebrand factor: a possible biomarker for disease activity in vasculitis
Authors' conclusion
vWF antigen serum level is increased in active vasculitis and could potentially serve as a biomarker for active disease.
Study context
- Population
- Adult patients with systemic vasculitis (40% AAV, 20% GCA, 16% PAN, 8% TAK, rest other vasculitides); mean age 56 ± 17 years, 56% women
- Participants
- 25 vs 15
- Exposure
- Patients with active systemic vasculitis vs healthy controls
- Vasculitisn = 25
- Healthy controlsn = 15reference
- Outcome
- Blood group-adjusted vWF antigen serum level as a possible biomarker of disease activity
- Follow-up
- At diagnosis
Methodological detailscase-control comparison with healthy controls, Disease activity recorded with Birmingham Vasculitis Activity Score (BVAS) version 3
- Case-control comparison with healthy controls
- Disease activity recorded with BVAS version 3
Main finding
As reported in the abstract
Blood group-adjusted vWF antigen serum level
P < 0.001
Observational data: associations, not effects.
Further findings
Von Willebrand factor (vWF) level at follow-up in patients reaching remission or low disease activity after treatment
- vWF level decreased significantly (13 patients)
vWF in patients treated with IL-6 inhibitors (subgroup)
- vWF elevated despite normal C- reactive protein (CRP) while vasculitis clinically active, in three out of five patients
- 3
Original publication
Von Willebrand factor: a possible biomarker for disease activity in vasculitis. Scand J Rheumatol. Published 5 February 2024. doi:10.
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