Value of the HFA-PEFF diagnostic algorithms for heart failure with preserved ejection fraction to the inflammatory myopathy population
Authors' conclusion
HFpEF was prevailing in IIM patients according to the HFA-PEFF score. The HFA-PEFF score correlated well with disease activity and held significant prognostic value. Patients with AMA-M2 antibody were prone to have poor outcomes.
Study context
- Population
- Patients with idiopathic inflammatory myopathy (IIM)
- Participants
- 220 patients
- Exposure
- Low vs intermediate vs high tertiles of the HFA-PEFF score
- Lown = 79reference
- Intermediaten = 107
- Highn = 34
- Outcome
- Prevalence of heart failure with preserved ejection fraction (HFpEF) in IIM via the HFA-PEFF score
Main finding
As reported in the abstract
Probability of HFpEF by HFA-PEFF score
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Overall survivalHigh vs Low · high-tertile score related to lower overall survival rate | P < 0.001 |
HFA-PEFF score and disease activity
- HFA-PEFF score correlated well with disease activity
HFA-PEFF score in AMA-M2 positive patients
- AMA-M2 positive patients scored higher in the HFA-PEFF score
- P = 0.011
Echocardiography during follow-up
- AMA-M2 or anti-SRP positive patients inclined towards concentric hypertrophy
Independent risk factors for high HFA-PEFF scores
- Palpitation, AMA-M2 positivity and elevated serum LDH, cTnI
Outcomes in AMA-M2 positive patients
- AMA-M2 positive patients had poorer outcomes
- P = 0.002
Original publication
Value of the HFA-PEFF diagnostic algorithms for heart failure with preserved ejection fraction to the inflammatory myopathy population. Arthritis Res Ther. Published 4 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →