Clinical features and prognosis of idiopathic inflammatory myopathy complicated by heart failure with preserved ejection fraction
Authors' conclusion
Our findings underscore the prognostic relevance of specific autoantibodies and cardiac fibrosis in IIM.
Study context
- Population
- Patients with idiopathic inflammatory myopathy (IIM) stratified by HFA-PEFF score
- Participants
- 134 patients
- Exposure
- High-risk vs intermediate- and low-risk HFA-PEFF categories in IIM
- High riskn = 22
- Outcome
- 5-year survival
- Follow-up
- 5 years
Methodological detailsstratified by HFA-PEFF score, Kaplan-Meier analysis, multivariable Cox regression
- Stratified by HFA-PEFF score
- Kaplan-Meier analysis
- Multivariable Cox regression
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| All-cause mortality, HFA-PEFF ≥5 (multivariable Cox)High risk vs Low risk · independent predictor | 3.124 | P < 0.05 |
- Late gadolinium enhancement on cardiac MRI in High risk
- 78.5%
Characteristics of High risk
- Older, lower free triiodothyronine, higher CRP and cardiac troponin T (all P < 0.05); greater prevalence of ILD with advanced pulmonary fibrosis
- Higher positivity for ANA, anti-SSA, anti-Jo-1 and anti-Ro52 (P < 0.05)
Original publication
Clinical features and prognosis of idiopathic inflammatory myopathy complicated by heart failure with preserved ejection fraction. Rheumatology (Oxford). Published 3 December 2025. doi:10.
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