The diagnostic value of serum YKL-40 for myocardial involvement in immune-mediated necrotising myopathy
Authors' conclusion
YKL-40 could be a promising non-invasive biomarker for diagnosing myocardial involvement in IMNM.
Study context
- Population
- Patients with Immune-mediated Necrotising Myopathy (IMNM) admitted to the Neurology Department, Tongji Hospital, April 2013–August 202229 IMNM, 15 controls
- Participants
- 14 / 15 / 15
- Comparison
- IMNM with vs without cardiac involvement on cardiac magnetic resonance (CMR); IMNM vs healthy controls
- IMNM with cardiac abnormalitiesn = 14
- IMNM without cardiac abnormalitiesn = 15reference
- Healthy controlsn = 15
- Outcome
- Diagnostic value (ROC AUC) of serum YKL-40 for cardiac involvement in IMNM
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
Serum YKL-40, median (IQR not labelled), by cardiac involvement on CMR
P = 0.002
- Specificity at cut-off 105.46 pg/ml for predicting myocardial injury
- 86.7%
- Sensitivity at cut-off 105.46 pg/ml for predicting myocardial injury
- 71.4%
Further findings
Pg/ml
| Outcome | IMNM with cardiac abnormalities | Healthy controls | P value |
|---|---|---|---|
| Serum YKL-40, IMNM vs healthy controls | 96.3 (range as printed 55.5 120.6) | 19.6 (range as printed 13.8 20.9) | P = 0.000 |
Original publication
The diagnostic value of serum YKL-40 for myocardial involvement in immune-mediated necrotising myopathy. Clin Exp Rheumatol. Published 1 March 2023. doi:10.
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