Association of diastolic dysfunction with myocardial tissue characteristics assessed by multi-parameter cardiac magnetic resonance in patients with idiopathic inflammatory myopathy
Authors' conclusion
LV diastolic dysfunction in IIM is closely linked to myocardial tissue characteristics, particularly in patients with concurrent active myocarditis and necrosis/fibrosis. Both active myocarditis and chronic myocardial fibrosis contribute to diastolic impairment.
Study context
- Population
- Idiopathic inflammatory myopathy (IIM) patients (56 late gadolinium enhancement (LGE)-negative, 26 LGE-positive) and controls82 IIM patients · 37 controls
- Participants
- 24 / 35 / 12 / 37
- Exposure
- IIM patients stratified by myocardial tissue characteristics vs controls
- Group 1n = 24
- Group 2n = 35
- Group 3n = 12
- Controlsn = 37reference
- Outcome
- Associations between LV diastolic dysfunction and myocardial tissue characteristics
Methodological detailsmulti-parameter cardiac MRI, linear regression
- Multi-parameter cardiac MRI
- Linear regression
Main finding
As reported in the abstract
Multivariable: Peak filling rate (PFR) inversely correlated with T2 value, β
−0.245
P = 0.042
Multivariable: Left ventricular (LV) global circumferential and longitudinal peak strains positively correlated with T2 value, β
0.288 and 0.276
P < 0.05
Observational data: associations, not effects.
Original publication
Association of diastolic dysfunction with myocardial tissue characteristics assessed by multi-parameter cardiac magnetic resonance in patients with idiopathic inflammatory myopathy. Rheumatology (Oxford). Published 13 October 2025. doi:10.
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