Differences in muscle magnetic resonance imaging findings between anti-signal recognition particle antibody-positive myopathy and anti-aminoacyl-tRNA synthetase antibody-positive myositis
Authors' conclusion
A comparison of thigh MRI between anti-SRP myopathy and anti-ARS myositis showed different findings and lesion sites reflecting the different pathophysiology that may contribute to their diagnosis.
Study context
- Population
- Patients newly diagnosed with polymyositis (PM)/dermatomyositis (DM) and immune-mediated necrotising myopathy (IMNM), positive for anti-SRP or anti-ARS antibodies, with thigh magnetic resonance imaging (MRI) at diagnosis; April 2012–December 2021of 98 PM/DM and IMNM patients
- Participants
- 5 / 11 / 22
- Exposure
- Anti-SRP myopathy vs anti-Jo-1 antibody-positive myositis vs non-Jo-1 antibody-positive myositis (thigh MRI findings)
- SRPn = 5
- Jo-1n = 11
- Non-Jo-1n = 22
- Outcome
- Lesion sites and thigh muscle MRI findings (oedema, fascial oedema, fatty replacement, muscle atrophy)
- Follow-up
- At diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Thigh MRI findings
- Oedema in most cases in both anti-SRP and anti-ARS groups
- Fascial oedema identified only in the ARS group, frequently in Jo-1 positive patients
- SRP vs ARS: P = 0.008
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Blood myogenic enzymes (e.g. serum CK)SRP vs Other groups · significantly higher in SRP | P = 0.01 |
Original publication
Differences in muscle magnetic resonance imaging findings between anti-signal recognition particle antibody-positive myopathy and anti-aminoacyl-tRNA synthetase antibody-positive myositis. Clin Exp Rheumatol. Published 15 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →