Changes in anti-MDA5 antibody titres and serum cytokine levels before and after diagnosis of anti-MDA5 antibody-positive dermatomyositis
Authors' conclusion
The anti-MDA5 antibody titre at diagnosis may predict the clinical course. Levels of macrophage-associated cytokines significantly declined at 6 months post-treatment, and they may have increased after anti-MDA5 antibody titre positivity.
Study context
- Population
- Patients with anti-MDA5 antibody-positive DM
- Participants
- 23 / 15 / 5 / 24
- Exposure
- Treatment response vs non-response; relapse vs non-relapse; before vs after diagnosis
- Responsen = 23reference
- Non-responsen = 15
- Relapsen = 5
- Non-relapsen = 24reference
- Outcome
- Whether anti-MDA5 antibody titres and cytokine levels predict clinical course; changes in both before and after diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Characteristics at diagnosis, non-response vs response
- Non-response group older, higher ground-glass opacity score, lower PaO2/FiO2, higher CRP and higher anti-MDA5 antibody titre than response group
- No cytokines significantly differed between groups at diagnosis
- Relapse group had significantly higher anti-MDA5 antibody titre than non-relapse group
Observational data: associations, not effects.
Further findings
Changes in survivors, 6 months post-treatment vs diagnosis
- Anti-MDA5 antibody titre and IFN-α, IFN-γ, MCP-1, IL-6, IL-33, CRP and ferritin significantly lower at 6 months post-treatment than at diagnosis
Cytokines before diagnosis in 3 patients anti-MDA5 antibody-positive before diagnosis
- Macrophage-associated cytokines (IL-6, IL-8, IL-18, MCP-1) increased after anti-MDA5 antibody positivity
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Changes in anti-MDA5 antibody titres and serum cytokine levels before and after diagnosis of anti-MDA5 antibody-positive dermatomyositis. Rheumatology (Oxford). Published 3 November 2022. doi:10.
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