Time-dependent changes in RPILD and mortality risk in anti-MDA5+ DM patients: a cohort study of 272 cases in China
Authors' conclusion
These results suggest significant, time-dependent changes in RPILD and mortality risk in anti-MDA5+ DM patients, providing a cut-off time window to estimate disease progression and poor prognosis.
Study context
- Population
- Patients with anti-MDA5+ DM, China
- Participants
- 272 patients
- Outcome
- Time-dependent risk of RPILD and death
Methodological detailsmultivariate Cox regression
- Multivariate Cox regression
Main finding
As reported in the abstract
RPILD occurring in the first 6 months after disease onset
>90%
Mortality occurring in the first 6 months after disease onset
84%
RPILD occurring in the first 3 months
50%
Deaths occurring in the first 3 months
46%
Observational data: associations, not effects.
Further findings
Independent risk factors for RPILD (multivariate Cox regression)
- Short disease course, high CRP, anti-Ro52 positive and anti-MDA5 titre (++∼+++) were independent risk factors of RPILD
Independent risk factors for death (multivariate Cox regression)
- High creatine kinase, high CRP and RPILD were independent risk factors for death
Original publication
Time-dependent changes in RPILD and mortality risk in anti-MDA5+ DM patients: a cohort study of 272 cases in China. Rheumatology (Oxford). Published 12 August 2022. doi:10.
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