Lupus & antiphospholipid syndrome
Value of Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study
Main findingResult — go to the resultSpearman ρ 0.709 95% CI 0.648–0.766Authors' conclusion
Compared with SLEDAI 2000, SLE-DAS may provide a more accurate disease activity assessment in patients with SLE, especially those with severe thrombocytopenia and cardiopulmonary involvement.
Study context
- Population
- Patients with SLE admitted at the Second Affiliated Hospital of Soochow University, January 2009 to December 2022
- Participants
- 396 patients
- Exposure
- SLE-DAS vs SLEDAI 2000 for assessing disease activity
- Outcome
- Clinical value of SLE-DAS for assessing disease activity, against glucocorticoid dose grading as gold standard
Methodological detailssingle-centre, glucocorticoid dose grading as gold standard, Spearman correlation analysis
- Single-centre
- Glucocorticoid dose grading as gold standard
- Spearman correlation analysis
Main finding
As reported in the abstract
Spearman ρ
0.709
95% CI 0.648–0.766
P < 0.001
By group
SLE-DAS
15.32
median · spread as printed 7.90–24.45
SLEDAI 2000
13
median · spread as printed 8–19
Observational data: associations, not effects.
Further findings
| Outcome | SLE-DAS | SLEDAI 2000 |
|---|---|---|
| Correlation with glucocorticoid dose grading based on disease activity grading | ||
| Spearman ρ (moderate) | 0.441 | — not stated in the abstract |
| Spearman ρ (mild) | — not stated in the abstract | 0.325 |
— not stated in the abstract
Correlation of score values with treatment variables (SLE-DAS correlated better than SLEDAI 2000)
- Glucocorticoid dose grading
- ρ=0.434 vs 0.518
- Gammaglobulin use
- ρ=0.170 vs 0.318
- Immunosuppressant use
- ρ=0.122 vs 0.221
Correlation with severe thrombocytopenia, cardiac and pulmonary involvement
- Positive correlation with SLE-DAS but not SLEDAI 2000
Original publication
Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study. Lupus Sci Med. Published 10 June 2024. doi:10.
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