Validation of International Classification of Diseases Code–Based Case Definitions of Immune Checkpoint Inhibitor–Associated Inflammatory Arthritis From Administrative Health Data
Authors' conclusion
ICD code-based case definitions of ICI-IA can accurately detect ICI-IA and can be used to support ICI-IA surveillance and research with administrative health data.
Study context
- Population
- Patients exposed to immune checkpoint inhibitors for cancer, CanRIO database (Canada): 100 with ICI-IA and 128 without ICI-IA100 ICI-IA, 128 without
- Participants
- 228 patients
- Comparison
- International Classification of Diseases (ICD) code-based case definitions of ICI-IA from administrative health data vs rheumatologist-confirmed ICI-IA
- Rheumatologist-confirmed ICI-IAn = 100reference
- Outcome
- Sensitivity and specificity of seven core ICD code-based case definitions of ICI-IA vs rheumatologist-confirmed ICI-IA
Methodological detailsvalidation study, stratified by sex, sensitivity testing with additional criteria
- Validation study
- Stratified by sex
- Sensitivity testing with additional criteria
Performance
As reported in the abstract
Diagnostic performance of the best case definition (≥1 PCD IA code)
| Test or model | Sensitivity | Specificity |
|---|---|---|
| ≥1 Physician Claims Database (PCD) IA code | 88.0% (95% CI 81.6%-94.4%) | 86.7% (95% CI 80.8%-92.6%) |
≥1 Physician Claims Database (PCD) IA code
Sensitivity88.0% (95% CI 81.6%-94.4%)
Specificity86.7% (95% CI 80.8%-92.6%)
- Sensitivity of the tested case definitions ranged
- 1.0% to 88.0%
- Specificity of the tested case definitions ranged
- 86.7% to 100.0%
Further findings
Performance by sex
- Case definition performances were similar between sexes
Sensitivity testing with additional criteria
- Additional criteria minimally improved specificity but sacrificed sensitivity
Original publication
Validation of International Classification of Diseases Code–Based Case Definitions of Immune Checkpoint Inhibitor–Associated Inflammatory Arthritis From Administrative Health Data. Arthritis Rheumatol. Published 20 April 2026. doi:10.
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