Ultrasound-detected inflammation and structural changes in the joints, tendons and entheses of patients with cancer who developed arthritis or arthralgia after exposure to immune checkpoint inhibitors
Authors' conclusion
This multicentre study reveals a higher burden of ultrasound-detected changes in ICI-arthritis compared with ICI-arthralgia, with diverse patterns across joints, tendons and entheses in both subtypes.
Study context
- Population
- Patients with cancer who developed new-onset arthritis or arthralgia after immune checkpoint inhibitor (ICI) therapy; US of 18 joints, 15 tendons and 5 entheses bilaterally (OMERACT definitions)
- Participants
- 101 patients
- Exposure
- ICI-arthritis vs ICI-arthralgia
- ICI-arthritisn = 48
- ICI-arthralgian = 53reference
- Outcome
- Prevalence and distribution of US-detected inflammation and structural damage in joints, tendons and entheses
Methodological detailsmulticentre, consecutive recruitment, six international centres
- Multicentre
- Consecutive recruitment
- Six international centres
Main finding
As reported in the abstract
US-detected synovitis
P < 0.001
Observational data: associations, not effects.
Further findings
US-detected synovitis, wrists
P < 0.001
US-detected synovitis, knees
P < 0.001
Tenosynovitis
P < 0.001
Peritendinitis
P = 0.099
Bone erosions
P = 0.027
'Active' enthesitis
'Active' enthesitis
- Similar between groups, no significant differences
Original publication
Ultrasound-detected inflammation and structural changes in the joints, tendons and entheses of patients with cancer who developed arthritis or arthralgia after exposure to immune checkpoint inhibitors. RMD Open. Published 5 October 2025. doi:10.
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