Outcomes of respiratory syncytial virus infection in patients with systemic autoimmune rheumatic disease
Authors' conclusion
This study highlights the increased risk of severe outcomes of RSV infection in individuals with SARDs. Factors associated with RSV hospitalization included frailty, higher comorbidity burden, and concurrent infection at the time of RSV.
Study context
- Population
- Individuals with systemic autoimmune rheumatic diseases (SARDs) and documented respiratory syncytial virus (RSV) infection, 2015–2023, Mass General Brigham (Boston, MA)mean age 68.5 years, 75.5% female
- Participants
- 188 individuals
- Outcome
- Hospitalization for RSV infection (risk factors)
Methodological detailsmultivariable adjusted logistic regression, electronic health records
- Multivariable adjusted logistic regression
- Electronic health records
Main finding
As reported in the abstract
Hospitalization and factors associated with it
- Hospitalized
- 96 (51.0%)
- Higher Charlson Comorbidity Index, aOR per point
- 1.16 (95% CI 1.04-1.31)
- Claims-Based Frailty Index, aOR vs robust/pre-frail
- 4.80 (95% CI 2.32-9.94)
- Concurrent infection, aOR vs RSV alone
- 2.52 (95% CI 1.07-5.92)
- CD20 inhibitor treatment, aOR vs csDMARD
- 3.84 (95% CI 0.99-15.20; numerically increased odds)
- Older age, OR per year
- 1.03 (95% CI 1.01-1.05; numerically increased odds)
Observational data: associations, not effects.
Further findings
Oxygen required, among hospitalized
- Required oxygen
- 56%
Deaths · within 90 days
- Deaths
- 12
- Of those hospitalized
- 12.5%
- Of all with RSV
- 6%
Original publication
Outcomes of respiratory syncytial virus infection in patients with systemic autoimmune rheumatic disease. Semin Arthritis Rheum. Published 4 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →